No abstract

on to idLntity the near naLivcs tor tht indavldual classes The sLonng functs ons based on the eomplementamties ot the mtertacLg regdrdmg hydrophobiLit} etectrestatic potLntiai and shape which highly rank near nativLs than othei models were constmcted using 73 non redundant hctLro d]mers The datasez consigtg of vdneus types of hekTo dimLrs whiclt could be classified mto at most 5 clusterg acLord]ng to the above ieaturcs usLd to identify the near natnes These c]usters cerrelate vith the groups based on the complex gtruLturub and the mterface shapeg ThL ]digest cluster contalns thu hetero dimems with globular shapes which rndy be stable In sornL sinall dusters, the hetero dimeTs with non g]obular shapes are mcluded They are often tTangiLnt uomplexes like the regent targLts in the CAPRI experiments Thus vife found that the hetero dimeTs arL strLLLturally veiy diL erse but that they could be classified into gcvLT t] groupb based on tlie abovc ftdtureb along with thL straetLLrdl mformatien even witheut theknowledgeaboutprotLiniunction 2P-045 S)-sth\esutI:Slt670f)i J･rV)4)/Fa)Mll[thEg:fi SullncggEvaltuzoollofActinFllainentbyMoleLularDynamicsAnalysis Yhin]i Wirtsushtta ll l) niui Aduchi fl 2) }itsuhiro inouc a 2) LdZtsaki deo a) and ,WbTahmo Sbkaberl " a Dopt Mlechameatl]ngtneeringcindSLrenee Ooto Linncni4, 2 Computational CettBiomechamcv ntzm Rl}CELY 3 Dept Plyviotogy Nbgopa bntverylij 4 JCQRPts(msTCtii thchanosengmg JSW Aczm cytoskeleLon, pdrt]Luldr]} its d}narmc reorgamzation pldys LTitica[ ro]es Ln a variety of inechamLal celluldr activities such as migrataon divsien and LeLl shape Lontrol The maJor component efactm cytoskeleton aetin filament has a double hehLal structurL Lollsibtmg o ± globula: actm mekLulLs Mechanicat stretLhing tvLisang dnd be]dmg cauge gtructural changLs m the double heheal fi]ament "hich must be a cnt]Lal step to mduce cytoskeleta1 ieerganiLation obselsed in the dbove mentioned Lellu!ar