The study involves determination of sun protection factor (SPF) values of some sunscreen formulations for their use in cosmetics.  The Sun Protection Factor (SPF) is a very popular instrument in the marketing of sunscreens. Sun protection factor is a laboratory measure of the effectiveness of sunscreen, the higher the SPF, the more protection a sunscreen offers against the ultraviolet radiations causing sunburn. It is often not understood how sunscreens work and where the limitations of the SPF are. A lot of aspects of the SPF are confusing, e.g. the race for higher and higher numbers, the effect on SPF when less sunscreen is applied and if sunscreen should be used at all because they may block the Vitamin D synthesis. The study explains how sunscreens work, how the SPF is determined and where the limitations of the current methods exist. The dynamic view of 'UV radiation applied' and the 'UV dose transmitted' through the sunscreen onto the skin as well as onto a substrate in vitro help in the understanding and are also promising approaches in the in vitro assessment. The study is helpful in selection of some sunscreens formulations used in cosmetics with better safety and high SPF values. Keywords: Sun Protection Factor, SPF, Sunscreens

The object of the present study is to develop sustained release system of the antihistaminic agent chlorpheniramine maleate generally used in allergic disorders common cold and other conditions. Matrix tablet is one of the least complicated devices to sustain the release of drug candidates. Different grades of polymers HPMC viz HPMCK4M and HPMCK15M were selected to sustain the release up to 12 hrs. Optimization techniques using factorial design for two factors at three levels (3 2 ) was selected to optimize varied response variables viz. release rate exponent (n), t50%, k, amount of drug released in 12h (Rel12h) and mean dissolution time MDT. The optimum formulations were selected and the results obtained with the experimental values were compared with the predicted values. In conclusion, the results suggest that the developed sustained-release matrix tablets could provide quite regulated release of chlorpheniramine maleate up to nearly 12 hr.

The Molecular formula of Diclofenac sodium is C 14 H 10 O 2 C L2 N.Na and chemical name, 2-[(2, 6dichlorophenyl)-amino] phenyl acetate. It is freely soluble in methanol, soluble in ethanol (95%), sparingly soluble in water and glacial acetic acid, practically insoluble in ether, chloroform and toluene.

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