Introduction: The spleen has considerable role in body's immunity. Indications for splenectomy have never been clearly dened. Though trauma is the most common indication, there are some non-traumatic conditions which warrant splenectomy eg. Incidental splenectomy in cytoreductive surgeries and splenectomy in chronic haemolytic disorders and other hypersplenism disorders. Also, potential complications following splenectomy have been discussed in this prospective observational study. Aims And Objectives: Ÿ To evaluate various diseases of spleen requiring its removal apart from trauma for a period of 18 months. Ÿ To study pattern of traumatic indication when non operative management fails Ÿ To study complications of splenectomy and prevention of sepsis Materials And Methods: 25 patients who were splenectomised in past one and a half year were analysed. Decision for splenectomy is based on grades of organ injury and hemodynamic stability andthose who were successfully managed with Nonoperative treatment were excluded. Complete evaluation including history recording and physical examinationwere done in all the nontraumatic cases. Prophylactic vaccinations were given in 20 patients, the specimens sent for histopathology were analysed.