Background: Caudal is a core promoter-preferential transcription factor. Results: We defined functional regions in Caudal that are important for core promoter-preferential activation and demonstrated that dCBP confers core promoter-preferential activation.
Conclusion:The unique combination of Caudal and dCBP enables co-activation in a core promoter-preferential manner. Significance: We provide mechanistic insights into core promoter-enhancer compatibility.
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