Motivation: Bipolar disorder (BD) and schizophrenia (SZ) has a difficult diagnosis, so the main objective of this article is to propose the use of Artificial Neural Networks (ANNs) to classify (diagnose) groups of patients with BD or SZ from a control group using sociodemographic and biochemical variables. Methods: Artificial neural networks are used as classifying tool. The data from this study were obtained from the array collection from Stanley Neuropathology Consortium databank. Inflammatory markers and characteristics of the sampled population were the inputs variables. Results: Our findings suggest that an artificial neural network could be trained with more than 90% accuracy, aiming the classification and diagnosis of bipolar, schizophrenia and control healthy group. Conclusion: Trained ANNs could be used to improve diagnosis in Schizophrenia and Bipolar disorders. upon the activation function [1]. The ANN inputs are multiplied by different weights to generate a predictive response. So, these responses in ANN are widely used for several applications such as classification and pattern recognition [2].This tool is effective modeling non-linear relationships that may be a promising candidate for differentiation for several biological processes [3]. ANN are used in medical field to analysis of sleep disorders, cytopathology and histopathology
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