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The World Health Organization (WHO), Recommends the exclusive breast-feeding until six months old. The breast milk is the perfect food for integral subsidize the all neonatal in this period. For possessing a rich lipids composition, highlighted the cholesterol, which have direct impact since on the first's years until the adult life. Sayed notability, this research brings a bibliograph review which objective is understand and stand out the importancy of the breast-feeding in the regulation of cholesterol metabolism and to quote the problems around this process. Breast-feeding has been described as an LDL reducer and HDL additive, referring to a lower LDL/HDL ratio in exclusively breastfed babies. This physiological metabolic transition, in the long run, influences the cholesterol composition in adults and yours metabolic strengthening, the reduction of the risk of hypercholesterolemia and the occurrence of CVD.