INTRODUCTION : The SARS-CoV-2 pandemic greatly influenced the overall quality of healthcare. The purpose of this study was to compare the time variables for acute stroke treatment and evaluate differences in the pre-hospital and in-hospital care before and during the SARS-CoV-2 pandemic, as well as between the first and second waves. PATIENTS AND METHODS : Observational and retrospective study from an Italian hospital, including patients who underwent thrombectomy between January 1st 2019 and December 31st 2020. RESULTS : Out of a total of 594 patients, 301 were treated in 2019 and 293 in 2020. The majority observed in 2019 came from spoke centers (67,1%), while in 2020 more than half (52%, p<0.01) were evaluated at the hospital's emergency room directly (ER-NCGH). When compared to 2019, time metrics were globally increased in 2020, particularly in the ER-NCGH groups during the period of the first wave (N= 24 and N= 56, respectively): “Onset-to-door”:50,5 vs 88,5, p<0,01; “Arrival in Neuroradiology – groin”:13 vs 25, p<0,01; “Door-to-groin”:118 vs 143,5, p=0,02; “Onset-to-groin”:180 vs 244,5, p<0,01; “Groin-to-recanalization”: 41 vs 49,5, p=0,03. When comparing ER-NCGH groups between the first (N=56) and second (N=49) waves, there was an overall improvement in times, namely in the “Door-to-CT” (47,5 vs 37, p<0,01), “Arrival in Neuroradiology – groin” (25 vs 20, p=0,03) and “Onset-to-groin” (244,5 vs 227,5, p=0,02). CONCLUSIONS : During the SARS-CoV-2 pandemic, treatment for stroke patients was delayed, particularly during the first wave. Reallocation of resources and the shutting down of spoke centers may have played a determinant role.