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Perspective │2 Artificial intelligence (AI) tools are increasingly being applied in drug discovery. Whilst some protagonists point to vast opportunities potentially offered by such tools, others remain skeptical, waiting for a clear impact to be shown in drug discovery projects. The truth is probably somewhere between these extremes, but it is clear that AI is providing new challenges not only for the scientists involved but also for the biopharma industry and its established processes for discovering and developing new medicines. This article presents the views of a diverse group of international experts on the 'grand challenges' for small-molecule drug discovery with AI and approaches to address them.

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Digital fabrication has been termed the “third industrial revolution” in recent years, and promises to revolutionize the construction industry with the potential of freeform architecture, less material waste, reduced construction costs, and increased worker safety. Digital fabrication techniques and cementitious materials have only intersected in a significant way within recent years. In this letter, we review the methods of digital fabrication with concrete, including 3D printing, under the encompassing term “digital concrete”, identifying major challenges for concrete technology within this field. We additionally provide an analysis of layered extrusion, the most popular digital fabrication technique in concrete technology, identifying the importance of hydration control in its implementation.