Complex endovascular repair of postdissection aneurysms is a safe procedure in patients deemed unfit for open surgery. Our experience suggests that close follow-up is mandatory as secondary procedures are frequently required to completely exclude the false lumen.

BeGraft stent grafts used as bridging stents during FEVAR are associated with favourable outcomes at 1 year follow-up. Long-term follow-up is required to confirm these promising results.

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separated into intima/media and adventitia wall layers, and analyzed with Affymetrix HTA 2.0 microarrays. The aortas were segmented from the CTAs into three-dimensional digital models, which were then subjected to finite-element analysis (FEA) without informing the software (VASCOPS A4clinics Research Edition) about age, gender, family history, or blood pressure. Peak wall rupture index (PWRI), derived from the FEA, was used as a marker of biomechanical rupture risk. Differential gene expression, adjusted for age and gender, was studied with R software. Enriched gene ontology processes were examined for annotated transcripts with the GOrilla and REVIGO online tools.Results: No transcript was significantly associated with PWRI after 5% false discovery rate correction was performed, in either media or adventitia. However, there were 1203 and 872 transcripts associated with PWRI at a nominal P of <.05 in media and adventitia, respectively. Analysis of enriched biological processes using the entire annotated transcript list ranked by fold-change revealed that extracellular matrix and structure organization in the media and nucleic acid metabolism and RNA metabolism in the adventitia were the most enriched biological processes in aneurysms with high PWRI.Conclusions: These results suggest that biomechanical rupture risk associates with expression of extracellular matrix genes as well as the level of bulk gene activity.