acidechanging polymorphisms between the BN reference genome and the genomic sequence of LE/Stm (https://rgd.mcw.edu/jbrowse). In summary, we identified three loci associated with cutaneous cyst formation (Ccd1, Ccd2, and Ccd3), located on Chrs 1, 8, and 11, with genomewide significance applying a genetic rat model, to our knowledge previously unreported. Ccd2 is homologous to the human TRICY1 region, which could further be narrowed down by genome comparison in both species. Future studies of this model and correlations with human data are likely to identify the genes predisposing to and involved in cutaneous cyst formation. Data availability statement Datasets related to this article can be found at https://data.mendeley.com/datasets/gp9k5y2y7 k/1, hosted at Mendeley (https://doi.org/1 0.17632/gp9k5y2y7k.1#file-725d5fdc-f13e-4d3f-a8ec-4059e1d98802).
Poikiloderma is a skin condition that combines atrophy, telangiectasia, and macular pigment changes (hypo-as well as hyperpigmentation). It is often mistaken for mottled pigmentation by general practitioners or nondermatology specialists. Poikiloderma can be a key presenting symptom of Rothmund-Thomson syndrome (RTS), dyskeratosis congenita (DC), hereditary sclerosing poikiloderma (HSP), hereditary fibrosing poikiloderma with tendon contractures, myopathy, and pulmonary fibrosis (POIKTMP), xeroderma pigmentosum (XP), Bloom syndrome (BS), Kindler syndrome (KS), and Clericuzio-type poikiloderma with neutropenia (PN). In these conditions, poikiloderma starts early in life, usually before the second or third year. They may also be associated with photosensitivity and other significant multi-organ manifestation developed later in life. Poikiloderma could indicate the presence of a genetic disorder with potentially serious consequences.Poikiloderma almost always precedes more severe manifestations of these genodermatoses. Prompt diagnosis at the time of presentation could help to prevent complications and mitigate the course of the disease. This review discusses these to help the practicing clinician manage patients presenting with the symptom. To further facilitate early recognition, this paper also proposes a simple diagnostic algorithm.
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