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This article reviews the current scenario and the main uncertainties and challenges associated with implementing Sustainable Aviation Fuel (SAF) in Colombia, from which it determines the possible certified technologies under the ASTM D 7566 standard as well as co-processing technologies contemplated within the ASTM D 1655 standard, more suitable for the implementation of SAF production. Likewise, through the PESTEL tool (Political, Economic, Social, Technological, Environmental, and Legal), a diagnosis is made in order to obtain an updated overview of the implementation of SAF in Colombia. Based on the above, it provides recommendations to mitigate the uncertainties identified, and it is complemented by the ECOCANVAS tool, which applies to businesses related to the circular economy, and also include the net production potential of SAF in Colombia, considering the production of feedstock, in agricultural residue of sugarcane, oil palm, corn, and coffee. This study concludes with some policy recommendations that can make SAF implementation viable and allow responsible institutions to organize themselves for better strategic action and identify the fields of research and the need for investment in R + D + i to strengthen the supply chain.