IVIL causes a considerable short-term transient rise in IOP. The IOP increase after IVIL can be statistically significant at 0 to 30 minutes after injection in both phakic and pseudophakic eyes, and tends to be greater in shorter eyes.

SUMMARYThe potential for ocular allergic patients to have a site specific antigen sensitisation was investigated using vari ous diagnostic tests of allergen sensitivity in subjects with allergic conjunctivitis (AC: n = 135), vernal keratocon junctivitis (VK: n = 20), rhinoconjunctivitis (n = 20) or rhinitis (N = 10). In the AC and VK patients, skin tests and conjunctival provocation tests (CPT) were per formed, and the levels of specific IgE in serum and in tears were identified. A subgroup of 36 patients was also challenged with a nasal-specific provocation test (NPT).Results showed a poor correlation between skin test results and tear-specific IgE, and also between serum specific IgE and tear-specific IgE in both AC and VK patients (K <0.3). CPT and tear IgE were significantly correlated (K = 0.5) in the ocular allergic population. In patients with rhinoconjunctivitis or rhinitis, and in 10 normal subjects, results of CPT and NPT were in 100% agreement. Conversely, in patients with only conjunctiv itis, little correlation was found between the results of CPT and NPT (K = 0.3). Tear-specific IgE was the only positive diagnostic sign of antigen sensitivity in 35% of VK patients and 30% of AC patients. These results sug gest that the conjunctiva can be a uniquely sensitised tar get organ in allergic patients.Conjunctival or keratoconjunctival allergic disease may at times be the only manifestation of allergen sensitivity pre sented by patients. While systemic tests can be useful in the diagnosis of ocular allergy, in a consistent percentage of cases of ocular allergy, tests such as the skin test and serum total and specific IgE are negative or not signifi cant. 1 In these patients the detection of specific IgE in tears and the response to specific conjunctival provocation tests From:

Intracorneal hematoma is a rare complication of canaloplasty for glaucoma. The blood can be removed without interrupting the Descemet membrane by partial-thickness paracentesis.

In order to assess the potential usefulness of CPT as a diagnostic tool for ocular allergy, the correlation between skin/RAST tests and CPT was determined in 144 patients affected by allergic 'hay fever' type conjunctivitis. The results showed that an agreement between skin/RAST tests and CPT occurred in 71% of the cases (130/183). Of the 29% uncorrelated cases, 23% (43/183) were positive for at least one specific antigen by skin/RAST tests but not by CPT, while 6% (10/183) were positive for at least one specific antigen by CPT, but not by skin/RAST tests. CPT dramatically increased the histamine levels in tears (p less than 0.001). These findings show that (1) systemic tests can be misleading in that they may suggest a specific sensitisation which, in fact, does not involve the conjunctiva (systemic test positive/CPT negative); (2) CPT can identify local conjunctival sensitisation in the absence of a systemic sensitisation (systemic test negative/CPT positive); (3) CPT can demonstrate that allergic 'hay fever' type conjunctivitis may be related to allergens different from those responsible for a systemic sensitisation.

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