Esophageal atresia, with or without tracheoesophageal fistula, and congenital duodenal obstructions are relatively frequent changes in the digestive tract in pediatric surgery. The combination of both, although described in the literature, is unusual. It is assumed that the early diagnosis with imaging tests and the combined surgical schedule, although still undefined, can reduce the mortality of these children. We report the cases of two newborns with esophageal atresia and congenital duodenal obstruction, concerning diagnosis, surgical treatment and clinical evolution.