Since the classic studies of Alexander Flemming, Penicillium strains have been known as a rich source of antimicrobial substances. Recent studies have identified novel metabolites produced by Penicillium sclerotiorum that have antibacterial, antifouling and pharmaceutical activities. Here, we report the isolation of a P. sclerotiorum (LM 5679) from Amazonian soil and carry out a culture-based study to determine whether it can produce any novel secondary metabolite(s) that are not thus-far reported for this genus. Using a submerged culture system, secondary metabolites were recovered by solvent extract followed by thin-layer chromatography, nuclear magnetic resonance, and mass spectroscopy. One novel secondary metabolite was isolated from P. sclerotiorum (LM 5679); the phenolic compound 5-pentadecyl resorcinol widely known as an antifungal, that is produced by diverse plant species. This metabolite was not reported previously in any Penicillium species and was only found once before in fungi (that time, in a Fusarium). Here, we discuss the known activities of 5-pentadecyl resorcinol in the context of its mode-of-action as a hydrophobic (chaotropicity-mediated) stressor.
RESUMO:O Estado é responsável por criar condições normativas e infraestruturais em um determinado território. Contudo, essas ações, em alguns casos, se mostram seletivas e restritas, como no caso das concernentes ao setor de transporte e logística. As ações do Estado brasileiro destinadas à fluidez territorial na atualidade são consubstanciadas, especialmente, pelo Programa de Aceleração do Crescimento (PAC). Dentro desse contexto de transformações territoriais advindas com esse programa, situamos nosso trabalho, que objetiva compreender como as ações do Estado concretizadas e planejadas no âmbito do PAC estão configurando ou podem configurar a logística territorial brasileira, particularmente, a do estado do Rio Grande do Norte. Palavras-chave: Programa de Aceleração do Crescimento. Logística. Fluidez Territorial. Rio Grande do Norte. ABSTRACT:The State is responsible for creating regulatory and infrastructural conditions in a given territory. However, these actions, in some cases, show selective and restricted, such as the actions for transport and logistics sector. The Brazilian State's actions for the territorial fluidity are realized through the Growth Acceleration Program (PAC). In this context of territorial changes brought about by the Program, we situate our work, which aims to understand how the State's actions implemented and planned in the PAC's scope are configuring or can configure the Brazilian territorial logistics, particularly the Rio Grande do Norte state.
Resumo Este artigo tem como propósito analisar as propostas de investimento em transporte e logística da Confederação Nacional da Indústria (CNI) e da Confederação Nacional do Transporte (CNT) para o estado do Rio Grande do Norte. A análise será desenvolvida a partir de três propostas realizadas pelas confederações, a saber: o Projeto Nordeste Competitivo da CNI, o Plano CNT de Transporte e Logística e, Projetos Prioritários de Duplicação de Rodovias: Propostas de Solução, também de autoria da CNT.Palavras-chave: fluidez territorial; planejamento; Confederação Nacional do Transporte; Confederação Nacional da Indústria; Rio Grande do Norte; Abstract This article has as purpose to analyze the investment proposals in transport and logistics of the National Confederation of Industry (CNI) and the National Confederation of Transport (CNT) for the Rio Grande do Norte state. The analysis will be developed from three proposals made by the confederations, to be specific: the Competitive Northeast Project (CNI), CNT Plan of Transport and Logistics and, Priority Projects of Highway Duplication: Proposed Solution (CNT).Keywords: territorial fluidity; planning; National Confederation of Transport; National Confederation of Industry; Rio Grande do Norte. ResuméCet article vise à analyser les propositions d'investissement pour le transport et la logistique de la Confédération nationale de l'industrie (CNI) et la Confédération nationale du transport (CNT), de l'état du Rio Grande do Norte. L'analyse sera développée à partir de trois propositions faites par les confédérations, à savoir: le projet nord-est compétitif de la CNI, le Plan CNT des Transports et de la Logistique, les projets prioritaires de Duplication des Autoroutes: Solution proposée, également rédigés par CNT.Mots-clés: fluidité territoriale; planification; Confédération nationale du transport; Confédération nationale de l'industrie; Rio Grande do Norte.
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