Deformation and subsidence measurements are very vital for stability of structures and buildings. Deformation and subsidence monitoring are easily carried out with the aid of established baselines. This study focuses on the establishment of baseline for monitoring deformation and subsidence within university of Lagos. Geodetic method of control establishment was adopted, where five (5) control stations were established on stable grounds across the university of Lagos main campus with Differential GPS observation carried out on them and data obtained were processed and analysed statistically. The result of the findings shows that the baseline established is very reliable, given that the vertical controls have their relative redundancy number rij ranging between 0.1<rij<1.0 and the standard deviations ranges from 0.002 to 0.005. Also, the relative precision of the established baselines fell within the range of 7.36e-06ppm-2.54e-05ppm. From the findings of this research, deformation and subsidence studies can be reliably monitored within the University of Lagos and its environ using the baseline established through this research in order to safeguard lives and properties – including high rise structures within the university’s main campus.