A BSTRACT Introduction: Tinea pedis is a dermatophyte infection of human feet, especially between the fingers and soles of the feet. Tinea pedis is caused by a fungal infection of Trichophyton rubrum . Red onion is one of the spices that has been widely known by the community and used as a traditional medicine in the prevention of fungus. The objective of this research was to determine the antifungal activity of gel produced from an extract of red onion on T. rubrum . Materials and Methods: The gel was formulated with various concentration of red onion, FI with a concentration of extract (5%), F2 (7.5%). and F3 (12.5%). Each formula tested the physical characteristics and antifungal activity toward T. rubrum . The antifungal activity was determined by the agar well-diffusion method using Saboround Dextrose Agar plates. Furthermore, the antifungal activities were assessed by the presence or absence of inhibition zones after the plates were incubated at 28 o C for 7 days. Results: F3 has the greatest inhibitory power than F1 and F2 ( P < 0.05). Then, F3 has the same inhibitory power as a positive control ( P > 0.05). Discussion: All gel understudy at various concentrations of red onion was formulated in gel-exhibited antifungal activity. Antifungal activity of red onion occurred because it contained allicin. Therefore, the researchers can use these gels as a natural antifungal in the healing of tinea pedis caused by T. rubrum . Conclusion: The gel from an extract of red onion showed significant antifungal activity against T. rubrum.
Kemangi (Ocimum basilicum L.) merupakan salah satu tanaman yang banyak dimanfaatkan sebagai bahan makanan, lalapan, dan sayuran pelengkap. Tanaman ini masuk ke dalam famili Lamiaceae yang mengandung berbagai senyawa kimia, di antaranya fenol, saponin, alkaloida, flavonoid, tannin, dan minyak atsiri. Bau badan dapat disebabkan oleh beberapa faktor seperti, faktor genetik, kondisi kejiwaan, faktor makanan, faktor kegemukan dan bahan pakaian yang dipakai. Salah satu pemicu bau badan karena adanya infeksi bakteri yaitu bakteri Staphyloccous epidermidis. Bakteri ini menyebabkan bau badan karena menghasilkan asam isovalerat. Penelitian ini bertujuan untuk memformulasikan deodoran spray minyak atsiri daun kemangi, menguji sifat fisik sediaan deodoran spray, dan mengetahui formulasi yang efektif sebagai antibakteri S. epidermidis yang menyebabkan bau badan. Hasil dari penelitian ini menunjukkan bahwa minyak atsiri daun kemangi mengandung linalool (3,42%) yang berpotensi sebagai antibakteri. Uji fisik dilakukan pada hari ke-0 (setelah pembuatan) dan ke-7 dengan hasil uji fisik sediaan secara organoleptis memiliki bau khas kemangi, berwarna keruh kekuningan, memiliki pH 4 yang kurang sesuai dengan pH kulit, dan mengalami kenaikan viskositas pada pemeriksaan hari ke-7. Hasil uji antibakteri dari formulasi 1, 2, dan 3 menunjukkan dayahambat berturut-turut 1,34; 13,22; dan 15,62 mm.
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