In search of some antimicrobial agents, synthesis of some Schiff base of cyanoacetohydrazide derivatives has been reported. The structures of all the synthesized compounds were established on the bases of various spectroscopic methods. All Schiff base were screened for antimicrobial activity. cyanoacetohydrazide were found to possess better antimicrobial potential.

ABSTRACT1,5-benzodiazepines have been synthesized by Nano Zirconia and Nano Sulfated Zirconia in solvent free conditions. Synthesis was carried out by conventional as well as microwave method. Benzodiazepines were synthesized by reacting o-phenylenediamine and few ketones in the presence of catalytic amount of Nanoparticles. Particles used were sized in between 53-100 nm. Nanoparticles were characterized by FT-IR, DLS and powder XRD analysis.

The title homoleptic Schiff base complexes, [M(C14H9Cl2N2O)2], for M = CoII, (I), and CuII, (II), present distinct coordination geometries despite the Schiff base dianion coordinating via the phenolato-O and imine-N atoms in each case. For (I), the coordination geometry is based on a trigonal bipyramid whereas for (II), a square-planar geometry is found (Cu site symmetry \overline{1}). In the crystal of (I), discernible supramolecular layers in the ac plane are sustained by chlorobenzene-C—H...O(coordinated), chlorobenzene-C—H...π(fused-benzene ring) as well as π(fused-benzene, chlorobenzene)–π(chlorobenzene) interactions [inter-centroid separations = 3.6460 (17) and 3.6580 (16) Å, respectively]. The layers inter-digitate along the b-axis direction and are linked by dichlorobenzene-C—H...π(fused-benzene ring) and π–π interactions between fused-benzene rings and between chlorobenzene rings [inter-centroid separations = 3.6916 (16) and 3.7968 (19) Å, respectively] . Flat, supramolecular layers are also found in the crystal of (II), being stabilized by π–π interactions formed between fused-benzene rings and between chlorobenzene rings [inter-centroid separations = 3.8889 (15) and 3.8889 (15) Å, respectively]; these stack parallel to [10\overline{1}] without directional interactions between them. The analysis of the respective calculated Hirshfeld surfaces indicate diminished roles for H...H contacts [26.2% (I) and 30.5% (II)] owing to significant contributions by Cl...H/H...Cl contacts [25.8% (I) and 24.9% (II)]. Minor contributions by Cl...Cl [2.2%] and Cu...Cl [1.9%] contacts are indicated in the crystals of (I) and (II), respectively. The interaction energies largely arise from dispersion terms; the aforementioned Cu...Cl contact in (II) gives rise to the most stabilizing interaction in the crystal of (II).

In search of some antimicrobial agents, synthesis of some Schiff base of cyanoacetohydrazide derivatives has been reported. The structures of all the synthesized compounds were established on the bases of various spectroscopic methods. All Schiff base were screened for antimicrobial activity. cyanoacetohydrazide were found to possess better antimicrobial potential.

1,5-benzodiazepines have been synthesized by Nano Zirconia and Nano Sulfated Zirconia in solvent free conditions. Synthesis was carried out by conventional as well as microwave method. Benzodiazepines were synthesized by reacting o-phenylenediamine and few ketones in the presence of catalytic amount of Nanoparticles. Particles used were sized in between 53-100 nm. Nanoparticles were characterized by FT-IR, DLS and powder XRD analysis.