The experience involves the use of a new foam dressing in conjunction with negative pressure wound therapy (NPWTi-D) to remove and cleanse infectious material from the wound. This paper evaluates the clinical results of patients who received VERAFLO treatment and dressing. The use of the innovative foam dressing to facilitate the evacuation of the infectious, viscous, and scabby material is regarded as a very novel and beneficial technique. According to studies, the success of the wound healing process depends not only on the features of the patient, but also on those of the wound. Expected healing with NPWTi is deemed fortunate because it guarantees that the damage has reached granulation and is, therefore, ready to be treated. Again, healthcare facilities must educate their staff on the significance of NPWTi in the operating room. VERAFLO CLEANSE CHOICE has consistently demonstrated its efficacy in eliminating infectious particles and exudate, ensuring the effective treatment of wounds. In conclusion, the approach is deemed effective since it reduces hospital mortality and length of stay and communicates the intricacies of injuries to neurosurgeons in order to choose the appropriate treatment procedures. This article evaluates the study’s methodology, findings, pathophysiology, biochemistry, genetics, scientific analysis, clinical implications, and unanswered questions concerning the removal and cleansing of infectious material from a wound using a novel technique that combines negative pressure therapy with instillation.