Most common prescriptions were moderate statins in UT patients and combination therapy in PT patients. The high discontinuation rate of HLD therapy in UT patients warrants further investigation and identification of methods to encourage and support long-term persistence.

This longitudinal cohort study analyzed hyperlipidemia (HL) therapy claims data.• Patients with type 2 diabetes mellitus or cardiovascular disease were included.• Adherence was ≥80% across most drug classes in both cohorts.• 12-month persistence rates were low and variable, and warrant further study.

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