BackgroundRhinovirus (RV) infections are the most common cause of viral upper respiratory infections (URIs), and in the majority of persons they are self‐limiting. However, in others, viral URIs can progress to bacterial sinusitis and induce chronic rhinosinusitis (CRS) exacerbations.MethodsWe conducted a comprehensive Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) review through April 2018 based on MEDLINE, EMBASE, Web of Science–Science Citation Index (SCI), and Conference Proceedings Citation Index‐ Science (CPCI‐S) using keywords: RV, respiratory virus, sinusitis, and airway epithelial cells. The goal of this systematic review was to: (1) determine the prevalence between RV and CRS, (2) study the changes that occur after experimental RV inoculation, (3) investigate the pathophysiologic mechanisms by which RV induces sinonasal inflammation, and (4) explore the treatment options available for RV‐associated sinusitis. Data regarding study design, research question, intervention, subjects, outcomes, and biases was extracted.ResultsThe initial search yielded 2395 unique abstracts, of which 614 were selected for full‐text review; 147 were included in the final review. We determined that (1) the prevalence of RV infections is increased in those with CRS, (2) humans challenged in vivo with RV secrete local inflammatory mediators with radiographic mucosal thickening, (3) RV species RV‐A and RV‐C challenges in vitro to sinonasal epithelia produce robust cytokine responses and differential gene changes, and (4) no current therapies have produced consistent and significant resolution of disease.ConclusionRV infections are common in persons with CRS, and incite inflammatory reactions that may result in CRS exacerbations and progression of disease. Further studies assessing RV species, and the host‐virome response are required to develop new strategies targeting RV‐induced CRS.

RATIONALE: Aspirin exacerbated respiratory disease (AERD) is a challenging upper and lower respiratory disease which requires joint management between allergists and otolaryngologists. Complete sinus surgery followed by aspirin desensitization (AD) appears to improve outcomes long-term. Recent studies have demonstrated a relationship between high preoperative, pre-AD sinonasal symptoms scores and severity of reactions during AD. In this study, we provide the first evidence for using stratified preoperative, pre-AD sinonasal symptom scores to predict postoperative, post-AD outcomes. METHODS: Retrospective chart review of all patients with aspirin challenge-proven AERD who underwent complete endoscopic sinus surgery followed by AD. Preoperative, postoperative/pre-AD, and short-(<2 months) and long-term (>6 months) postoperative/post-AD sinonasal symptom scores were collected (22-item Sino-Nasal Outcomes Test, . A longitudinal linear mixed-effects model was used for data analysis. RESULTS: Preoperative SNOT-22 scores (n547) were divided into tertiles (cutoffs of 36 and 54 indicating mild [22.5613.7], moderate [44.3612.2], and severe [72.9619.7] disease). Postoperative, pre-AD SNOT-22 in all disease groups decreased and were not significantly different (12.3613.7, 11.1612.2, and 22.7619.7; p50.074). Following AD, only the severe group scores worsened (35.0620.3, p<0. Abstracts AB61 SATURDAY