An increasing number of patients are surviving critical illness, but some experience new or worsening long-lasting impairments in physical, cognitive and/or mental health, commonly known as post-intensive care syndrome (PICS). The need to better understand and improve PICS has resulted in a growing body of literature exploring its various facets. This narrative review will focus on recent studies evaluating various aspects of PICS, including co-occurrence of specific impairments, subtypes/phenotypes, risk factors/mechanisms, and interventions. In addition, we highlight new aspects of PICS, including long-term fatigue, pain, and unemployment.

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I would like to thank my parents for their endless support. For their guidance and providing me with the chance to pursue my dreams. I would also like to thank my advisor Dr. Sahin for his continuous support, guidance and the trust he places on us his students, for being a great teach, mentor and most of all a great friend. Celal, thank you for your friendship. it has been a absolute pleasure for me to have you as friend, a brother, a teacher and mentor. Thank you for all the times you have been there of me, for everything you have tough me. Finally, I would like to thank Lilian, my oldest and best friend, for her continuous support ever since we were undergraduate, through out my masters It has been an honor be a part of the Multi-Agent Bio-robotics Laboratory family For the rest not mentioned I thank you all.

Free-Space optical (FSO) link is an optical communication technology that uses light or laser as the carrier diffuses into free space to transfer data information between the transmitter and the receiver through the air channel. In this paper, a dual transmitters and receivers with multi-beam technique were designed to Study the effects of rain attenuation on the system to be used through FSO during the rainy weather. FSO model system was designed and simulated using OptiSystem7.0 software. The results analysis of FSO link within (1.6 - 3.9 km) ranges according to a Charbonneau model for rain attenuation. The transmitting data with NRZ modulation was designed and analysis of the performance System efficiency parameters such as bit error rate (BER) and Q. Factor for different optical links. The results of the simulation showed that the received signal power decreases and the bit error rate is increasing when the rain rate is increasing.