Introduction: Anesthetic gases are very important for health among health care worker (HCWs) and patients in medical centers. Operating rooms (ORs) is the most important ward that use anesthetic gases. Isoflurane gases is very dangerous for HCWs. Objective: In this study, we have associated the concentration of anesthetic toxic isoflurane gases (ppm) and the health risk assessment due to exposure to common anesthetic gases in Valiasr and Shahid Beheshti teaching hospital operating room during 2018. Methods: In this study, we used the active sampling system by portable pump SKC and tubes (sorbent Tube Tenax TA 250 mg) for detection of isoflurane concentration (ppm). Different points of the operating rooms were selected for sampling. Hazard index (HI) quantified by calculating the non-cancer causing anesthetic toxic isoflurane gases. Results: According result this study, the Valiasr and Shahid Beheshti had the lowest and the highest level of isoflurane. Based on result this study, level of isoflurane on indoor air quality in the operation room in Valiasr and Shahid Beheshti hospital were 2.129 and 2.436 ppm, respectively. According to the results from the current study, hazard index was under 1.0 and it amount showed that no significant risk of adverse health endpoint attributed to exposure to level of isoflurane in Valiasr and Shahid Beheshti teaching hospital operating room during 2018. Conclusion: According Result this study the average concentration of isoflurane and the health risk assessment in Valiasr and Shahid Beheshti teaching hospital operating room during 2018 because of flaw in the ventilation system was significantly higher than standard.

Abstract Crimean-Congo Hemorrhagic Fever (CCHF) is a tick-borne, viral disease that may also be transmitted through person-to-person transmission by exposure to infected body fluids. It causes a severe disease in humans with high mortality rates. Here we present two cases of CCHF patients with sudden onset of lethargy, fever, nausea, vomiting, headache, and hemorrhagic manifestation. With one of the patients tick bite was confirmed, then he was treated with ribavirin in isolation and recovered completely. The second patient was in contact with the infected blood of a sheep and, unfortunately, despite the treatment, he passed away. Public health measures should focus on preventing this infection by raising the awareness of CCHF symptoms and route of its transmission, and also by adopting practices to decrease the chances of spreading infections in hospitals.

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