Evaluation of splenic enlargement is important in the diagnosis and management of various diseases including liver disease, lymphoma and other primary or metastatic neoplasm. This cross sectional study was conducted in the Department of Radiology and Imaging in Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) from July 2007 to June 2009. The main objective of the study was to find out a more accurate sonographic measurement of splenic volume that well correlate with gold standard computed tomography (CT) volume. A total of 228 subjects were included in the study. All the subjects underwent ultrasound and CT examinations for measurement of splenic volume. 3 . Sonographic splenic volumes were calculated by using the prolate Ellipsoid method AVL (average length) and also expressed in cm 3 .The mean difference of splenic volume evaluated by CT and sonography was 7.43±5.39 cm 3 with standard deviation of 5.39 cm 3 measured from average length (AVL). The mean difference of splenic volume evaluated by two modalities measured by average length was statistically significant (p<0.05).A significant positive correlation was found between splenic volume evaluated by CT and ultrasonogram by using the Prolate Ellipsoid method AVL (r=0.9854, p<0.001).

A 10 year old male child reported to paediatric neurology OPD of BIRDEM General Hospital with the complaints of weakness of left side of body, seizure and facial asymmetry for 2 years. He was on regular anti convulsive therapy and failed to control seizure. General examination revealed no significant abnormality neither delayed mile stones of development happened. Neurological examination revealed left sided spastic hemiparesis, brisk tendon reflexes and extensor planter on left side. With detailed history and examination he was diagnosed as a case of infantile seizure and undergone CT scan of brain followed by MRI scan. Both the reports revealed severe atrophy of right cerebral hemisphere, thinning of cortical gyri, widening of sulci and dilatation of right lateral ventricle with ipsilateral midline shift and was concluded as hemiatrophy of right cerebral hemisphere with suspicion of Dyke Davidoff Masson Syndrome (DDMS), Hemimegalencephaly and Sturge-Weber syndrome. Dyke-Davidoff-Masson syndrome (DDMS) is a rare condition characterized by asymmetric cerebral hemispheric growth with unilateral atrophy, ipsilateral compensatory osseous hypertrophy, hyperpneumatization of the paranasal sinuses and mastoid cells, and contralateral paresis. Varying degrees of hemiparesis, hemiplegia, seizures, mental retardation, and facial asymmetry can be associated with DDMS. Considering clinical history and imaging findings, final Diagnosis was Dyke Davidoff Masson Syndrome. Birdem Med J 2013; 3(2): 196-109 DOI: http://dx.doi.org/10.3329/birdem.v3i2.17215

Abstract:Background: Microalbuminuria is associated with increased cardiovascular mortality in type 2 Diabetes mellitus. Carotid intima media thickness reflects index of cardiovascular disease. There is increased prevalence of microalbuminuria found in type 2 diabetes. So there is a positive correlation between microalbuminuria and carotid intima media thickness in type 2 diabetic subjects.Objective: This study was performed to find out correlation between microalbuminuria and ultrasonographically measured carotid intima media thickness in type 2 diabetic subjects.

Insulin is a lifesaving hormone which is secreted from beta cell of Pancreas. It helps to reduce high blood sugar in the blood by trapping the glucose molecule and enter into cell. Now a day, insulin resistance diabetes mellitus (IRDM) becomes a serious public health problem in the world and also a great headache to the scientific communities. That’s why, world scientist are enormously seeking the alternative of insulin or insulin like effective drugs. It has been proved that nature is having all remedies to combat disease related morbidity and mortality. We have to search, we have to know, we have to identify and we have to apply appropriate technology to evaluate new molecules, new metabolites or active compounds for reducing the devastating effects of diabetes as well as insulin resistance diabetes mellitus. Evidence based studies showed that berbery, bitter melon, cinnamon tree, gardenia, korean pine, little dragon, mango, pygeum, fenugreek and lychee composed of incretins mimetic compounds. But isolation of active metabolomics and the multicentre base clinical trials are needed to propagate the herbal medicine in the world. It is an attempt to amalgamate, to congregate, to concise some incretins mimetic medicinal plants which will help to get new generic compound and also give new clue for further research on DM.