The aim of this study is to determine the potency of drug available in our market in Bangladesh. Diclofenac Sodium is a potent Non-Steroidal Anti-Inflammatory Drug (NSAID) and that are widely used and it is an Over the Counter (OTC) drug in Bangladesh. Potency determination was performed to evaluate that the marketed sample comply with the declared specification or not. In vitro Dissolution study was performed to see that if potency is high

This study concentrates on dissolution of drug in presence of fruit juice specifically mango juice. This work aspires current research to study the dissolution approach pattern of commercial formulation of metronidazole in Bangladesh commercially available eight brands of metronidazole film coated tablets were studied in gastric medium (pH 1.2). All brands got reasonably higher dissolution release mainly M02 (84.79%), M05 (75.86%), M06 (72.53%) and M07 (86.48%) were released relatively faster than other sample in 15 to 50 minutes. Therefore, Mango juice assists to enhance the therapeutic response of metronidazole on set of quick response.

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Objectives: To explore the risk factor, prevalence and treatment pattern for patient with osteoarthritis, to survey the socio-demographic information of the patient, to compare the number of affected gender, to know their pain mode, to know the percentage treatment pattern and to identify the outcome of the treatment. Methodology:The study design was a non-experimental retrospective survey. Total number of sample was 200 osteoarthritis patient's documents. Results:Result shows that 30-64 years age group were most affected and female were mostly affected by osteoarthritis. Among them the rate of housewife was 39%. They are more vulnerable. Effectiveness of treatment and complementary and alternative therapy was good. Percentage of improvement or satisfied with the treatment was approximately 49%. In total achievement, approximately 17% aims of treatment are not satisfied due to some causes and 34% have no improvement since many of them are new patient. Conclusion:Osteoarthritis is a common physiotherapy related problem. Because it is not a curable disease but regular physical exercise, treatment can reduce the symptoms.

The aim of this present work is to investigate the antimicrobial, antioxidant and cytotoxic activities of methanol extract of Polygonum orientale (Family: Polygonaceae). Antimicrobial activity of methanol extract of Polygonum orientale was tested by Disc Diffusion Method. Standard antibiotic discs of Kanamycin (30µg/disc) for bacterial species was used as standard and crude extracts were used at a concentration of (20mg/disc) and (40mg/disc) for leaves and (10mg/disc) and (20mg/disc) for shoot extracts. The methanol extracts of leaves and shoots showed mild activity against gram positive bacteria, gram negative bacteria and fungi. Most of the organisms were susceptible to the extract in various degrees. The extract showed highest zone of inhibition (13mm) against the Gram (+)ve Bacillus megateriumand and gram (-)ve Escherichia coli (zone of inhibition 10mm). Antioxidant property of the plant extracts against stable DPPH (1, 1-Dipheny1-2-picrydrazole) radical was investigated. Ascorbic acid was used as standard. The extract was found low in antioxidant property. The absorbance was taken at 517nm by UV Spectrophotometer. The IC50 values were found in leaf extract and shoot extract are (1244.58µg/ml and (1506µg/ml). For ascorbic acid IC50 value was (139.19µg/ml). Cytotoxic activity of the crude extract by using Brine Shrimp Lethality Bioassay. Vincristin sulphate was used as standard. LC50 value of leaf extract was found (6.85µg/ml) and (9.7104µg/ml) for the shoot extract. In conclusion, the extract of the experimental plants have mild antimicrobial, low antioxidant and good cytotoxic properties.