The present study was aimed to find out the phenyl propanoids HPTLC profile of the medicinally important plant Albizia lebbeck Benth. HPTLC studies were carried out following Harborne and Wagner et al. method. The Toluene-ethyl acetate (9.3:0.7) was served as mobile phase for phenyl propanoids. Linear ascending development was carried out in 20 cm x 10cm twin trough glass chamber (Camag, Mutenz, Switzerland) saturated with the mobile phase and the chromatoplate development for two times with the same mobile phase to get good resolution of phytochemical contents. The developed plate was sprayed with Vanillin sulphuric acid reagent as spray reagent and dried at 120° C in hot air oven for 10 min. (14) of phenyl propanoids has been observed in ethyl acetate extracts and petroleum ether followed by ethyl acetate (13) extracts of A. lebbeck leaves. The results of the present study developed novel phytochemical marker to identify the medicinally important plant. Further advanced spectroscopic and chromatographic studies will lead for the structural elucidation and identification of active components present in the leaves of A. lebbeck.

In this context, natural products derived from the biological sources have emerged as the first choice of researchers. Accordingly, several plant-/fungal-/bacterial-derived natural products are in diff erent stages of evaluation as new therapeutic agents (Veeresham, 2012 andBernardini et al., 2017). There has been also a growing interest among the researchers for exploring synthetic derivatives of natural products as a novel class of drugs with multiple activities and target specificity. In

Eco-friendly biopolymers, polyhydroxybutyrate, have been produced by many kinds of bacteria that possess most important applications in food packaging industries and also in medical field. In the present work, PHB production was economized through the statistical optimization of physical variables. The physical variables chosen for the enhanced production of PHB were incubation period, temperature, pH and inoculums size. The relative rate of production has been studied by understanding the complex interactions of variables using face-centred central composite design. The submerged fermentation with Acinetobacter nosocomialis RR20 produced PHB yield of 5.88 g/L at optimized conditions with a notable value change of sixfold increase in comparison with minimal salt medium and these findings have showed that the designed medium was significant in terms of higher of PHB production.

Natural products and associated combination therapy have gained prominent role in decreasing the adverse effects of synthetic drugs engaged in the severity of colon cancer. D-Limonene a dietary monoterpene and hispolon a bioactive polyphenol proven to be anticancer agents independently against several cancers. The current study is designed to examine complimentary anticancer effect of D-limonenehispolonconcoction in COLO-205 and HCT-116 cell lines. Collectively, our cell viability, cell migration, clonogenic tests and CompuSyn analysis results exemplified that the combination of D-limonene and hispolonnatural products eminently effective against colon cancer cell lines.Gastric cancer patients are reported to develop severe side effects due to the currently available chemotherapy,our combinational anticancer therapy bydietary natural compounds would be highly beneficial to the patients.

Passiflora caerulea L. (blue passion flower) is a member of the genus Passiflora, which contains over 500 species and is popular worldwide for its diverse medicinal properties. Qualitative phytochemical screening was carried out for the methanolic extract of the plant leaves and the tests revealed that the plant contains a wide range of medicinally important secondary metabolites such as alkaloids, cyanogenic compounds, phenolic compounds and glycosyl flavonoids. Among a host of organic solvents which were used for extraction, the methanolic extract was particularly found to possess high concentrations of carbohydrates, glycosides, free amino acids, glycosides, fats and alkaloids. Also, flavonoids, phytosterols, saponins, tannins and other phenolic compounds were present at lower levels in the methanolic extract. We tested the antioxidant potential of the P. caerulea methanolic leaf extract and discovered that it possessed nitric oxide scavenging activity of close to 80% w.r.t at 100 μg/mL against ascorbic acid control (100%). In the ABTS and DPPH radical scavenging assays, the extract (100 μg/mL) possessed antioxidant potential of 72.3% and 70%, respectively, w.r.t ascorbic acid control taken at 100 μg/mL. The plant powder was assessed quantitatively for presence of carbohydrates, proteins, lipids, ascorbic acid, tannins and flavonoids and the concentrations of these compounds were found to be 14.26 mg/g, , respectively. MTT assay results showed that the crude methanolic extract of the plant possessed appreciable activity against breast cancer (MCF-7) cells. Although the IC50 values of the extract against MCF-7 cells were much lesser comparatively w.r.t control doxorubicin, the crude extract possessed considerable activity against MCF-7 cells when compared to the standard drug, doxorubicin. These results necessitate deeper investigations into the pharmacological and therapeutic usefulness of purified compounds from P. caerulea. Though P. incarnata is the most widely studied species in the Passiflora genus, P. caerulea is relatively poorly studied. This paper shows the phytochemical composition and biological activities of P. caerulea.