No abstract

A self-organized wireless communication short-lived network containing collection of mobile nodes is mobile ad hoc network (MANET). The mobile nodes communicate with each other by wireless radio links without the use of any pre-established fixed communication network infrastructure or centralized administration, such as base stations or access points, and with no human intervention. In addition, this network has potential applications in conference, disaster relief, and battlefield scenario, and have received important attention in current years. There is some security concern that increases fear of attacks on the mobile ad-hoc network. The mobility of the NODE in a MANET poses many security problems and vulnerable to different types of security attacks than conventional wired and wireless networks. The causes of these issues are due to their open medium, dynamic network topology, absence of central administration, distributed cooperation, constrained capability, and lack of clear line of defense. Without proper security, mobile hosts are easily captured, compromised, and attacked by malicious nodes. Malicious nodes behavior may deliberately disrupt the network so that the whole network will be suffering from packet losses. One of the major concerns in mobile ad-hoc networks is a traffic DoS attack in which the traffic is choked by the malicious node which denied network services for the user. Mobile ad-hoc networks must have a safe path for transmission and correspondence which is a serious testing and indispensable issue. So as to provide secure communication and transmission, the scientist worked explicitly on the security issues in versatile impromptu organizations and many secure directing conventions and security measures within the networks were proposed. The goal of the work is to study DoS attacks and how it can be detected in the network. Existing methodologies for finding a malicious node that causes traffic jamming is based on node’s retains value. The proposed approach finds a malicious node using reliability value determined by the broadcast reliability packet (RL Packet). In this approach at the initial level, every node has zero reliability value, specific time slice, and transmission starts with a packet termed as reliability packet, node who responded properly in specific time, increases its reliability value and those nodes who do not respond in a specific time decreases their reliability value and if it goes to less than zero then announced that it’s a malicious node. Reliability approach makes service availability and retransmission time.

Background: Oral cancer (OC) is serious health concerning issue that has a high fatality rate. The oral cavity has seven kinds of OC, including the lip, tongue, and floor of the mouth, as well as the buccal, hard palate, alveolar, retromolar trigone, and soft palate. The goal of this study is to look into new biomarkers and important pathways that might be used as diagnostic biomarkers and therapeutic candidates in OC. Methods: Publicly available repository the Gene Expression Omnibus (GEO) was responsible to collect OC-related datasets. GSE74530, GSE23558, and GSE3524 microarray datasets were collected to apply analysis. Minimum cut-off criteria of |log fold-change (FC)| > 1 and adjusted p < 0.05 were applied to figure out the up-regulated and down-regulated differential expression genes (DEGs) from the three datasets. After that only common DEGs in all three datasets were collected to apply further analysis. Gene ontology (GO) and Pathway analysis were implemented to explore the functional behaviors of DEGs. Then protein-protein interaction (PPI) networks were built to identify the most performed genes, clustering algorithm was also implemented to identify complex parts of PPI. TF-miRNA networks were also constructed to study deeply about OC-associated DEGs. Finally, top gene performers from PPI networks were used to apply drug signature analysis. Results: After applying filtration and cut-off criteria 2508, 3377, and 670 DEGs were found for GSE74530, GSE23558, and GSE3524 respectively, and 166 common DEGs were found in every dataset. The GO annotation remarks that most of the DEGs were associated with the terms of type I interferon signaling pathway. The pathways of KEGG reported that the common DEGs are related to the Cell cycle and Influenza A. The PPI network holds 88 nodes and 492 edges and CDC6 had the highest number of connections. 4 clusters were identified from the PPI. Drug signatures doxorubicin and resveratrol showed high significance according to the hub genes. We anticipate that our bioinformatics research will aid in the definition of the pathophysiology and the development of new therapies for OC.