No abstract

The present study was designed to investigate the phytochemical screening, the free radical scavenging activity and to determine the total phenolic content of methanolic extract and different solvent soluble fractions of Averrhoa bilimbi Linn. (Oxalidiaceae) fruits. The free radical scavenging activity was evaluated by analyzing the bleaching rate of 1,1-diphenyl-2-picrylhydrazyl (DPPH), and total phenolic content was determined by using Folin-Ciocalteau reagent, which results were expressed in gallic acid equivalent (mg of GAE/g of sample). The phytochemical screening revealed the potent source of different phytochemical constituents on different extractives including, phenol, flavonoid, tannin that are responsible for antioxidant action. In the determination of total phenolic content, different extractives showed a significant content of phenolic compounds ranging from 50.23-68.67 mg of GAE/g of extractive. The plant sample displayed significant DPPH free radical scavenging activity with highest IC50 value in crude methanolic extract (30.365 ?g/ml) followed by chloroform, carbon tetrachloride, pet-ether and aqueous soluble fractions having value of 32.852 ?g/ml, 36.708 ?g/ml, 50.35 ?g/ml, and 79.918 ?g/ml, respectively as opposed to that of the scavenging effects of BHT of 19.656 ?g/ml.DOI: http://dx.doi.org/10.3329/icpj.v2i4.14058 International Current Pharmaceutical Journal, March 2013, 2(4): 92-96

Thrombolytic therapy, also known as clot busting drug, is a breakthrough treatment which has saved untold lives. It has been used in the clinical area to treat venous and arterial thromboembolic complaints which are a foremost cause of death. In 1761, Morgagni lead the way of thrombolytic therapy. Now day's different types of thrombolytic drugs are currently available in market: alteplase, anistreplase, urokinase, streptokinase, tenecteplase, and so forth. Thrombolytic therapy should be given with maintaining proper care in order to minimize the risk of clinically important bleeding as well as enhance the chances of successfully thrombolysis of clot. These cares include preinfusion care, during the infusion care, and postinfusion care. Besides proper knowledge of contraindication, evolutionary factor, and combination of drug is essential for successful thrombolytic therapy. In these review we discussed about these aspect of thrombolytic therapy.

No abstract

The study proves that the crude methanolic extract of Enhydra fluctuans Lour. has significant antioxidant, anthelmintic and thrombolytic activity containing wide range of phytochemicals.