Aims: Lablab purpureus (Fabaceae) a well-known Bangladeshi vegetable combines a great number of qualities with its adaptability and functional food properties. But still there is no evidance based report on neuropharmacological activities of Lablab purpureus seeds. For this reason, the present study was designed to analyze in vivo CNS effect of methanolic extract of Lablab purpureus seeds. Place and Duration of Study: Department of Pharmacy, USTC between April 2017 and May 2018. Methodology: In this study, the crude seeds extract of Lablab purpureus was evaluated for its sedative and anxiolytic effect using animal behavioral models, such as open field and hole cross tests for its sedative properties and an elevated plus maze (EPM) test for its anxiolytic potential. Results: In open field and hole cross test, the seeds extract of Lablab purpureus showed a dose dependent suppression of motor activity and exploratory behaviour. In EPM test, animals treated with higher dose of methanolic extract showed significant (p<0.01) increased exploration to and time spent in EPM open arms. Conclusion: This study provide in vivo evidence that the methanolic extract of Lablab purpureus has significant sedative and anxiolytic activity. Further studies on active constituent of the extract can provide approaches for therapeutic intervention.

Cocos nucifera (L.) (Arecaceae) is commonly called the ‘‘coconut tree’’ and is the most naturally widespread fruit plant on Earth. Throughout history, humans have used medicinal plants therapeutically, and minerals, plants, and animals have traditionally been the main sources of drugs. The objective in the present study was to screen the phytochemical profile and pharmacological activities of methanolic extract of coconut leaves. To investigate pharmacological activities DPPH scavenging assay and HRBC membrane stabilization methods were performed for antioxidant and anti-inflammatory potential respectively. The phytochemical analysis of methanolic extract of coconut leaves showed that they contained significant presence of flavonoids, phenols , saponins, terpenoids and triterpenes. Alkaloids, glycosides and tannins are also moderately present. Quantitative evaluations show significant presence of phenols which was more than tannin content. The pharmacological studies revealed that the plant extracts may have significant antioxidant effect which is probably mediated by inhibition of DPPH free radical. The IC50 values by DPPH scavenging assay observed for standard and leaves were 97.29µg/ml and 486.78µg/ml respectively. Thus, this plant extracts have significant antioxidant effect. It also had moderate anti-inflammatory activity. The IC50 values for anti-inflammatory activity by standard and coconut leaves were 21.46 µg/ml and 831.21 µg/ml respectively. These findings suggest that Cocos nucifera (L.) may be a possible source for the development of a newanti-inflammatory drug.