Borderline personality disorder (BPD) is characterized by instability in affect, interpersonal relationships, and impulsivity ( APA, 2013 ); individuals with BPD have elevated shame-proneness ( Scheel et al., 2013 ), including higher baseline levels of ( Scheel et al., 2013 ), and greater reactivity to, shame ( Gratz et al., 2010 ). Shame, an aversive self-conscious emotional state wherein one experiences the self as both flawed and unacceptable ( VanDerhei et al., 2014 ), has putative links to both self-destructive and self-protective domains of sexuality; namely, sexual self-esteem ( Heinrichs et al., 2009 ) and sexual risk-taking ( Overstreet, 2012 ). The current research investigated (1) relations between elevated BPD symptom severity and sexuality, and (2) whether shame-proneness could mediate relations between BPD symptom severity and sexuality domains in an undergraduate sample. Participants included 167 women undergraduate psychology students ( Mage = 20.42, SD = 4.82) who completed measures of BPD symptom severity, shame-proneness, sexual self-esteem, and safe sex behaviour. Shame-proneness partially mediated relations between BPD symptom severity and both sexual self-esteem (6.79% variance) and sexual risk-taking (2.82% variance). Potential implications include understanding how proneness to shame may enhance likelihood of sexual risk-taking behaviour and/or low sexual self-esteem, and whether shame-targeted interventions could mitigate the ramifications of shame on these domains of sexuality in individuals with higher BPD symptom severity.