Social infrastructure provides the development of the territory of regions and countries. Public-private partnership is currently one of the most important tools for modernizing social infrastructure. A modern analysis of publications on infrastructure development shows a high interest of scientists in this issue: The relationship between quantitative and qualitative indicators of infrastructure functioning and socio-economic development of territories, and the dysfunction of management practices are studied. At the same time, the scientific literature does not sufficiently study issues related to a comprehensive assessment of the level of development of public-private partnership, restrictions, and prospects for interaction between government and business on the development of social infrastructure at the regional level. The purpose of this article is to identify the limitations and prospects of interaction between government and business on the development of social infrastructure at the regional level in the Russian Federation based on an integrated assessment of the level of PPP development. The main method of this research is an expert survey of civil servants and representatives of the business community in the Moscow region. The results of the study revealed a low level of mutual trust between business and government, and an average level of PPP development at the regional level. It is concluded that to assess the depth of development of the PPP mechanism in the region, it is necessary to include criteria that demonstrate the evaluation of these projects by the PPP participants themselves. Assessment of the level of PPP in the region should be integral, contain both quantitative indicators (financial and economic) and qualitative (assessment of PPP participants). The strategic direction of PPP development should be to increase the involvement of all stakeholders, taking into account their views in making management decisions in this area. This will help to increase the transparency and openness of the relevant procedures and will allow timely identification of dysfunctions that arise as a result of interaction between government and business.