The aim of the research is to study effectiveness of nano particle of cow bone ash to substitute SP36 synthetic fertilizer on cultivation of maize (Zea mays Saccharata Sturt) in entisol soil. The method used in this research was completely randomized block design with single factor of 5 treatments. The treatments were 100% of SP36 & 0% nanoparticle as control, 75 % of SP36 & 25 % of nano particle of cow bone ash, 50 % of SP36 & 50 % of nano particle of cow bone ash, 25 % of SP36 & 75 % of nano particle of cow bone ash. and 0 % of SP36 & 100 % of nano particle of cow bone ash. Parameters used in this study were the growth and yield of sweet corn. The results revealed that application of nano particle of cow bone ash could substitute synthetic fertilizer of SP-36 in the range of 25 to 100 % of growth and yield of maize. The application of treatment 25 % of SP36 & 75 % of nano particle of cow bone ash could increase cob weight of maize about 24 ton per ha or could increase the yield about 35 % compared to 100% SP36.