Highlights d Devise methods to quantify antibody responses targeting the base of HIV-1 Env trimers d Fusion-peptide (FP) priming reduces anti-base responses upon HIV Env trimer boost d Lower percentage of anti-base responses correlates with improved neutralization breadth

Highlights d Trispecific bNAbs reduce viremia 100-to 1000-fold in viremic SHIV-infected macaques d After treatment completion in these macaques, long-term viral control is CD8-mediated d Trispecific but not parental bNAbs suppress the emergence of resistant virus in culture

No abstract