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95% CI-6.14 to-1.54; moderate certainty and MD-5.77, 95% CI-8.76 to-2.78; moderate certainty, respectively). In very low certainty evidence, the effects of acupressure, telephone support, and meditation were uncertain. There were few or no data on adverse events related to psychosocial interventions. Conclusions: Using cognitive-behavioural therapy, exercise, counselling, or relaxation techniques probably reduces depressive symptoms for adults with ESKD treated with dialysis. Cognitive-behavioural therapy and exercise probably increase health-related quality of life. Evidence of other psychosocial interventions is uncertain.