CP, Carr IM et al. Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. Nat Genet 2008; 40: 789-793. 3 Zhang Z, Xia W, He J et al. Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy. Am J Hum Genet 2012; 90: 125-132. 4 Coggins KG, Coffman TM, Koller BH. The Hippocratic finger points the blame at PGE2. Nat Genet 2008; 40: 691-692. 5 Riviere PJ, Farmer SC, Burks TF et al. Prostaglandin E2-induced diarrhea in mice: importance of colonic secretion.

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