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In this study, we report the synthesis and antibacterial activity of a new series of 5-amido-1-(2,4-dinitrophenyl)-1H-4-pyrazolecarbonitriles. Our results show that all compounds exhibit antimicrobial activities against methicillin susceptible Staphylococcus aureus and methicillin resistant S. aureus with MIC values of 25.1 and 91.0 lM.

Nucleophilic substitution of hydrogen in nitro derivative of imidazo[1,2‐a]pyridine has been used as a key step in the one‐pot synthesis of a new highly fluorescent heterocyclic system pyrido [1″,2″:1′,2′]imidazo[4′,5′:5,6]pyrido[2,3‐b]indole. J. Heterocyclic Chem., (2012).

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