ABS TRACT Coronavirus disease-2019 (COVID-19), the plague of our time, affects many systems. Kidney involvement may cause acute kidney injury by affecting proximal tubules along with other probable sites. Although renal effects of COVID-19 have been reported in adults, pediatric data are limited. A five-year-old, previously healthy boy hospitalized for COVID-19 infection, developed polyuria on the 3 rd day of his admittance. Laboratory workup was compatible with proximal renal tubulopathy and normal clinical and laboratory status was achieved within 5 days with only conservative therapy. Laboratory findings were normal at the first month out-patient visit. We hypothesize that the transient proximal tubulopathy experienced in our case is related to COVID-19 infection. Clinicians should keep in mind the potential tubular involvement in children with COVID-19 infection.