Baseline proteinuria was significantly correlated with ∆%GFR per year. Hypertension and proteinuria were found to be the major treatable risk factors for the progression of CKD in ADPKD patients.

Introduction Despite recent advances in surgical techniques, pancreatic fistulas are common. We aimed to determine the role of C-reactive protein in the prediction of clinically relevant fistula development. Materials and Methods Data from patients who underwent pancreaticoduodenectomy between 2012 and 2015 is collected. Postoperative 1st, 3rd, and 5th day (POD1, POD3, and POD5) C-reactive protein (CRP) levels, postoperative pancreatic fistula (POPF) development, other complications, length of hospital stay, and mortality were recorded. Results Of 117 patients, 43 patients (36.8%) developed complications (including fistulas). Of the patients developing fistulas, 21 (17.9%) had POPF A, 2 (1.7%) had POPF B, and 7 (6.0%) had POPF C. POD5 CRP and POD3 CRP were shown to be significantly correlated with mortality and development of clinically relevant POPF (p = 0.001 and p = 0.0001, resp.) and with mortality (p = 0.017), respectively. The development of clinically relevant POPFs (B and C) could be predicted with 90% sensitivity and 82.2% specificity by POD5 CRP cut-off level of 19 mg/dL and with 100% sensitivity and 63.6% specificity by the difference between POD5 and POD1 CRP cut-off level of >2.5 mg/dL. Conclusion CRP levels can effectively predict the development of clinically relevant pancreatic fistulas.

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Basal cell carcinoma is exceedingly common, but giant basal cell carcinomas (GBCCs) are rare. We retrospectively reviewed 34 patients with GBCC on the head and neck region treated with aggressive surgical excision and reconstruction in a single operative procedure.The large defects were reconstructed with 15 free tissue transfers and 20 pedicled muscle, musculocutaneous flaps, and skin flaps. We were able to observe 23 patients for a minimum 5 years after the surgery. Locoregional recurrence and/or distant metastasis were not observed in 22 patients. Only 1 patient with the scalp BCC had local recurrence between the flap and the normal tissue 2 years after the surgery. Recurrent tumor was widely excised and reconstructed with a skin graft. Our results imply that low complications, good oncologic control, and acceptable cosmetic results can be achieved by a 1-stage team approach with aggressive surgical resection and reconstruction.