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ÖZET SUMMARY Investigation of in vitro Effects of Various Antibiotic Combinations Against Acinetobacter Species Especially in recent years, Acinetobacter spp. gained resistance to almost all antimicrobial agents caused by increased invasive diagnostic and therapeutic procedures and, use of extended spectrum antibiotics. This is an important clinical problem for hospitalized patients and therefore new treatment options such as combination therapy are needed for treatment of infections caused by those bacteria. In this study we aimed to investigate the in vitro effects of colistin-sulbactam, imipenem-sulbactam, imipenem-amikacin and rifampin-azithromycin combinations on multidrug resistant (MDR) A.baumannii strains. In this study 40 A.baumanii strains isolated from various clinical specimens sent from different clinical departments to Atatürk University Medical School Clinical Microbiology Laboratory and resistant to at least three antibiotic groups were included. All isolates were identified by standard methods and VITEK 2 automated system. Antibiotic susceptibility tests were performed by disk diffusion method on Mueller-Hinton Agar and VITEK 2 automated system and results were interpreted according to the recommendations of Clinical and Laboratory Standarts Institute (CLSI). Species kept frozen at -80°C until tested. Pseudomonas aeruginosa ATCC 27853 and Escherichia coli ATCC 25922 were used for quality control. Gradient diffusion method was used to investigate the in vitro effects of colistin-sulbactam, imipenem-sulbactam, imipenem-amikacin and rifampin-azithromycin combinations on MDR A.baumannii strains. Effect of antibiotic combinations to bacteria was determined by fractional inhibitory concentration (FIC) index. FIC index results were interpreted as follows

ÖZET Üriner sistem infeksiyonlarında Genişlemiş Spektrumlu Beta-Laktamaz (GSBL) üreten Escherichia coli ve SUMMARY Investigation of the Activity of Fosfomycin and Nitrofurantoin to Extended Spectrum Beta-lactamase Producing Escherichia coli and Klebsiella pneumoniae Strains Isolated from Hospitalized Patients with Urinary Tract Infections The isolation of extended-spectrum beta-lactamase (ESBL) producing Escherichia coli and Klebsiella pneumoniae in urinary tract infections constitutes an important therapeutic challenge. In this study in vitro susceptibility of fosfomycin and nitrofurantoin against ESBL-producing isolates consisting of 71 Escherichia coli and 27 Klebsiella pneumoniae isolated in Ataturk University

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