Purpose To evaluate the repeatability of wavefront aberration measurements and the correlation between corneal aberration and pupil size in normal eyes using a wavefront-based autorefractor (i.ProfilerPlus; Carl Zeiss Vision, Germany). Methods A prospective cross-sectional study. Wavefront aberrations, including SA (Z40), coma (Z3 − 1, Z31), trefoil (Z3 − 3, Z33) and total higher-order aberrations (tHOA), were measured at different pupil diameters. The repeatability was evaluated using one-way ANOVA method, and statistical indicators including within-subject standard deviation (Sw), test-retest repeatability (TRT), and intra-class correlation coefficient (ICC). The correlations between corneal aberrations and pupil sizes were evaluated by Pearson correlation analysis. Results A total of 96 healthy young volunteers were enrolled. Corneal and ocular higher-order aberrations (HOA) measured by i.Profiler showed Sw<0.01µm, TRT < 0.10µm, ICC > 0.90. There was a linear positive correlation between the corneal HOA and pupil size. The correlation coefficient between SA and tHOA was the largest (r = 0.996, P < 0.001). Conclusions The measurements of wavefront aberrations by i.Profiler are highly repeatable. Corneal HOA is significantly dependent on pupil size. SA is the most influential aberration for visual quality.

To evaluate the repeatability of wavefront aberration measurements and the correlation between corneal aberration and pupil size in normal eyes using a wavefront-based autorefractor (i.Pro ler Plus ; Carl Zeiss Vision, Germany). MethodsA prospective cross-sectional study. Wavefront aberrations, including SA (Z 4 0 ), coma (Z 3 − 1 , Z 3 1 ), trefoil (Z 3 − 3 , Z 3 3 ) and total higher-order aberrations (tHOA), were measured at different pupil diameters. The repeatability was evaluated using one-way ANOVA method, and statistical indicators including withinsubject standard deviation (S w ), test-retest repeatability (TRT), and intra-class correlation coe cient (ICC).The correlations between corneal aberrations and pupil sizes were evaluated by Pearson correlation analysis. ResultsA total of 96 healthy young volunteers were enrolled. Corneal and ocular higher-order aberrations (HOA) measured by i.Pro ler showed S w <0.01µm, TRT < 0.10µm, ICC > 0.90. There was a linear positive correlation between the corneal HOA and pupil size. The correlation coe cient between SA and tHOA was the largest (r = 0.996, P < 0.001). ConclusionsThe measurements of wavefront aberrations by i.Pro ler are highly repeatable. Corneal HOA is signi cantly dependent on pupil size. SA is the most in uential aberration for visual quality. Key MessagesThe i.Pro ler (Carl Zeiss Vision, Germany) is a novel device that comprehensively assesses visual quality by measuring both lower-and higher-order aberrations at a wide pupil range (2 to 7mm).Excellent repeatability of the i.Pro ler has been shown in measuring refraction, however, repeatability data of higher-order aberration measurements are lacking.This study shows the repeatability of the i.Pro ler in measuring wavefront aberrations and the correlation between corneal aberration and pupil size.