Background: The detection rate and drug resistance rate of K. pneumoniae increased year by year in China. Understanding the drug resistance situation will help guide prevention and control of K. pneumoniae infection. Methods: This study collected the results of drug susceptibility of K. pneumoniae from six tertiary hospitals in Shaoxing city in 2019 and analyzed the differences in drug resistance among different hospitals, genders, ages, and specimens. Results: A total of 1954 strains were collected, all of which were most sensitive to amikacin, with a resistance rate of 4.42%. The resistance rate to carbapenems and tigecycline was less than 10%. Nitrofurantoin had the highest resistance rate (36.18%). The drug resistance rate of Shaoxing traditional Chinese medicine hospital and Shaoxing maternity and child health care hospital was lower, and the drug resistance rate of the affiliated hospital of Shaoxing University was the highest. In addition to the Shaoxing maternity and child health care hospital, specimens were mainly from elderly and male patients, the drug resistance rate increased with age, and no carbapenem-resistant strains were found in patients under 17 years old. The specimens were mostly from the respiratory tract and urinary tract, but the CRKP rate was the highest in blood, the ESBL rate was the highest in other sterile body fluids except for blood, and the high ESBL and CR rates in urine were also detected. Conclusions: The above results indicated that there were significant differences in drug resistance rates of strains among different hospitals, genders, ages, and specimen sources, and clinical empirical medication should be incorporated into the reference.