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A global and regional prediction and evaluation model of plastic pollution is proposed. We have collected the data of global plastic production and plastic related indicators of hundreds of countries in the past 100 years, and established a global disposable plastic waste accumulation prediction model based on time series model and multiple linear regression. Our model suggests that the earth’s disposable plastic waste will accumulate to the maximum level in 2054, but if we do not intervene in the current development trend of plastic waste, the whole ocean will be seriously polluted in 2024. We divide 145 countries into four categories by clustering algorithm, and establish multiple linear regression models with different leading factors, so as to put forward regional countermeasures. We use factor analysis method to evaluate the plastic pollution in 136 countries, so that the countries can control the plastic pollution more pertinently.