The article examines the problems of innovative transformations of domestic industries in view of the state and attractiveness of the innovative environment, in which the leading place belongs to scientific research. It was noted that among all spheres of activity, it was science that suffered the most significant losses. In Ukraine, there is a tendency to reduce the number of researchers, which leads to a gradual degradation of the scientific potential. The state of technology transfer according to the first, second and third strategic priorities is of concern because this is a real sector of the economy on which the country's competitiveness depends and which needs reengineering transformations in the first place. The concept of technological reengineering in conditions of clustering of the national economy relies on enterprises of the high-tech sector. The science-intensive sector in Ukraine generates GDP at the level of the most backward countries in the world due to too few types of economic activity (FDI) that meet the criteria of high technology. At the same time, its share of added value in output is the largest among other technological sectors. This shows that science produces high-tech and competitive products. The cluster with its system of connections is aimed at creating systems of machines that meet the needs of the market. For modern clusters of knowledge-intensive production, such a task can be accomplished if attention is focused not only on resource provision, but also on various (several) determinants of market demand, which are formed on the types of market activity. It is justified that the cluster with its communication system is aimed at creating machine systems that meet the needs of the market. The combination of all components of the effect has a positive effect on the readiness of firms and organizations to cooperate with cluster structures, and this is a factor of regional development.