Ogilvie syndrome (colonic pseudoobstruction); is acute and excessive dilatation of the colon without mechanical obstruction. 1 Its etiology is not fully known. Approximately 90% of patients have noncolon diseases such as metabolic or organic dysfunctions, postoperative or posttraumatic conditions. 2 While it is common after pelvic fractures and spine surgery, it can also be seen with hospitalization in the intensive care unit, infection and pharmacological agents used. Few cases have been reported after central nervous system pathologies or operations. It is thought to occur as a result of centrally affecting the autonomic nervous system. 3 In this case report, we aimed to present 2 patients who developed Ogilvie syndrome while they were being followed up in the service after postoperative neurosurgical surgery at different times.

Fampridine, (4-AP, 4-Aminopiridin dalfampridine), potasyum kanallarını bloke ederek etki eden ve sinir hasarında etkili olan bir ilaçtır. Multipl skleroz (MS), omurilik yaralanmaları, Lambert-Eaton sendromu ve miyastenia gravis gibi hastalıkların tedavisinde kullanılmaktadır. Literatürde fampiridin toksisitesine yönelik oldukça az sayıda olgu bulunmaktadır. Oldukça ciddi yan etkileri olan bu ilacın toksik alımlarında antidot tedavi bulunmamaktadır fakat semptomatik tedaviye erken başlanmalıdır. Burada fampridin toksisitesi ile yoğun bakımda takip edilen bir olgu sunulmuştur.