Introduction:The antiinflammatory and antioxidative effects of melatonin have been established in recent years. Several studies indicate that oxidative stress and inflammation are key drivers of post-coronary artery bypass graft (CABG) surgery complications. In the present study, we aimed to investigate the effects of melatonin on cardiac injury and inflammatory biomarkers in CABG candidates. Methods: Embase, Medline/PubMed, Web of Science, Scopus, and the Cochrane library were searched up to 5 June 2022. All randomized controlled trials examining cardiac injury and inflammatory biomarkers of CABG patients who received melatonin were included. The random-effects model was utilized to perform the analysis. Results: A total of 947 citations were retrieved through database searches. Finally, five articles (six trials with 342 patients) were included after the screening. Melatonin supplementation led to a significant reduction in cardiac troponin I (CTnI) [weighted mean difference(WMD): -2.28 ng/ml; 95% CI -2.87, -1.69; P \ 0.01; I 2 : 91.25%] and high sensitivity-C reactive protein (hs-CRP) levels

Introduction: Collagen VI-related disorders are a group of heterogeneous muscular diseases due to mutations within the COL6A1, COL6A2, and COL6A3 genes, encoding collagen VI as an essential component of the extracellular matrix. Here, we reported four patients affected by collagen VI-related disorders with genetic variants in COL6A genes. Case Presentation: After a comprehensive clinical examination, four unrelated patients with muscular dystrophy were referred for genetic counseling. Whole-exome sequencing followed by Insilco analysis was done for one affected individual from each family. The analysis of genomic data revealed four different mutations within the COL6A1, COL6A2, and COL6A3 genes in the affected individuals. Conclusions: According to the previous reports, limb-girdle muscular dystrophy is inherited as autosomal dominant, and congenital myosclerosis phenotype is inherited in an autosomal recessive manner. Carrier testing and prenatal testing are possible if pathogenic variants are recognized in an affected family member.