Background:The results of the Indonesian Basic Health Research in 2018 stated that the index for tooth extraction reached 7.9%, higher than treatments with fillings (4.3%) and scaling (1.4%). Actions resulting from tooth extraction that are slow to heal can cause complaints including pain, swelling, bleeding, and even infection, so proper post-extraction management is needed to reduce the possibility of complications. The drug that is often used for wound healing is glycerin iodine, but iodine itself has irritating and toxic properties if it enters the blood vessels, so glycerin iodine needs to be given another alternative as an antiseptic or healing agent after tooth extraction. Objectives: This review aimed to determine the bioactive substances and the effect of Gallus domesticus egg white gel in increasing the number of fibroblast cells in the wound healing process after tooth extraction through a literature study from researchers which was used as a reference for making this literature review. Method: Data were obtained by data collection methods related to the study being studied and analyzed descriptively. Results: Several literatures conclude about bioactive substances and the effect of Gallus domesticus egg white gel in increasing fibroblast cells. These literatures discuss the effect of using egg white gel in the wound healing process that can stimulate fibroblast cells, antiviral, antibacterial, and growth factors. Implications: This review is expected to provide information in the health sector, especially in the oral cavity about the potential of Gallus domesticus egg white gel as a traditional medicine for wound healing which is relatively inexpensive, easy to obtain and practical.