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A new series of 2,3-disubstituted quinazolin-4(3H)-one derivatives bearing triazole and thiadiazole nucleus has been synthesized and then screened for their urease inhibition properties. All synthesized compounds showed outstanding urease inhibitory potentials with IC 50 values ranging between 0.25 ± 0.01 and 18.00 ± 0.64 μg/mL when compared with standard inhibitors thiourea (IC 50 = 15.08 ± 0.71 μg/mL) and acetohydroxamic acid (IC 50 = 21.05 ± 0.96 μg/mL). All new molecules were characterized by 1 H NMR, 13 C NMR, and MS.

A new series of ciprofloxacin hybrid compounds as new type of antimicrobial agents were synthesized and evaluated for antibacterial activity against Gram‐positive and Gram‐negative bacteria.

Background: The synthesis of new hybrid molecules consisting of several heterocyclic pharmacophores namely fluoroquinolone, 1,2,4-triazole, 1,3,4-oxadiazole and piperazine was carried out by conventional and successfully optimized microwave mediated techniques. Methods: The structures of new compounds were confirmed using spectroscopic techniques. These compounds were screened for their antibacterial activity against E. coli, P. aeruginosa, Y. pseudotuberculosis, S. aureus, E. faecalis, B. cereus and M. smegmatis. Results and Conclusion: Fourteen of these hybrids exhibited excellent antibacterial activities on the test microorganisms when compared with ampicillin with the mic values varying between 0.03- 0.25 µg/mL.

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