The organic-inorganic hybrid H 5 [Ag 2 (hyp) 2 ] 2 [BW 12 O 40 ]· 9H 2 O (1) (hpy = hypoxanthine), based on Keggin-type polyoxometalate and hypoxanthine, was prepared by hydrothermal synthesis and characterized by single-crystal and powder X-ray diffraction, IR spectroscopy, elemental analysis, and thermogravimetry. The title com-925 pound has a two-dimensional layer structure constructed by Keggintype [BW 12 O 40 ] 5anion, silver, and the biomolecule hyp. In addition, compound 1 exhibited excellent stability and superior activity in the electro-catalytic oxidation of glucose.