Background: Based on the transcriptome high-throughput sequencing of non arteritis anterior ischemic optic neuropathy, this study constructed a competitive endogenous RNA (CeRNA) network , enriched and analyzed it, screened lncRNA and circRNA that may participate in the competitive endogenous mechanism in NAION, and inferred its function. Methods: 4ml peripheral blood of NAION patients and control group were extracted from clinical samples, and the transcriptome high-throughput sequencing was performed, and the sequencing data were visualized; Based on the principle of CeRNA network, lncRNA-miRNA-mRNA interaction axis and circrna-miRNA-mRNA interaction axis were constructed respectively; The differentially expressed genes in the interaction axis were enriched and analyzed by GO and KEGG, and the functions and signal pathways of lncRNA and circRNA in the interaction network were speculated. Results: 51 circRNAs were differentially expressed in the sequencing data: 25 were up-regulated and 26 were down-regulated; There were 996 differentially expressed lncRNAs: 317 were up-regulated and 679 were down-regulated; 1161 differentially expressed mRNAs: 698 were up-regulated and 463 were down-regulated. 33 differentially expressed miRNAs, up-regulated mirna18 and down-regulated 15. After screening, the co-expressed 13 mRNAs, 15 lncRNAs and 3 miRNAs were finally constructed in lncRNA-miRNA-mRNA network and the circRNA-miRNA-mRNA network were constructed by 159 mRNAs, 26 miRNAs and 34 circRNAs. In the lncRNA network , GO enrichment analysis obtained 182 biological processes, 12 cell components and 38 molecular functions, which are mainly related to the activity regulation of proteins and enzymes such as cyclic nucleotide dependent protein kinase activity and magnesium ion dependent protein serine / threonine phosphatase activity. KEGG analysis mainly involves FOXO signal pathway, Apelin signal pathway, etc. In the result of circRNA enrichment, 353 biological processes, 52 cell components and 45 molecular functions were obtained, mainly involving calcium channel regulation, neutrophil activation, mRNA transport and metabolism. KEGG mainly involves Wnt signaling pathway, Apelin signaling pathway, Hippo signaling pathway, oxytocin signaling pathway, etc. Conclusion: This paper provides a new idea for lncRNA and circRNA to mediate the occurrence and development of NAION through CeRNA mechanism. It lays a foundation for the in-depth study of pathogenesis of NAION.