Herein, the first catalytic protocol for nickel-catalyzed ortho or para position difluoromethylation of various aromatic amines has been developed with the assistance of a bidentate phosphine ligand, offering an invaluable synthesis means to construct extensive p-difluoromethylated products and difluorooxindole derivatives with significant functional fragments. Furthermore, the gram-scale reaction, broad substrate scope, excellent functional-group compatibility, late-stage difluoromethylation of pesticides, and even formal synthesis of HDAC6 inhibitors further demonstrate the usefulness of this method.Letter pubs.acs.org/OrgLett

The first catalytic protocol for regioselective [3+2] annulation of N-methyl pyridinium ylides with alkenes to establish various valuable 3-unsubstituted indolizine derivatives is accomplished by palladium catalysis in the unactivated position....