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Keeping a coating–substrate system undamaged during heavy-load elastohydrodynamic lubrication (EHL) conditions is challenging. To overcome this problem, an EHL model with a coated gear pair was built. Firstly, based on the full-system finite element method, the effect of the coating elastic modulus on the oil film pressure was obtained. Secondly, the failure mode was predicted after the stress analysis. Finally, the surface/interface damage evolution behavior of the coating–substrate system was analyzed visually by embedding cohesive zone elements. In the numerical calculation, stiffer coatings tended to increase the film pressure and secondary pressure spike, compared with more compliant coatings. As the coating stiffness decreased, the maximum equivalent stress in the system reduced, and its location tended to develop close to or at the substrate. The coating cracking and interfacial delamination were individually caused by the shear stress in the coating and shear stress on the interface, and both of them initiated in the region of the secondary pressure peak. The interfacial delamination increased the crack failure probability of coating and vice versa. Therefore, through analyzing the EHL model, the exact damage growth location and its evolution in the coated solids can be determined, and the failure mechanism can be comprehensively revealed.

Background. Emerging evidence has shown that two common genetic polymorphisms within the pleckstrin domain-containing protein 5 (DEPDC5), rs1012068 and rs5998152, may be associated with the risk of hepatocellular carcinoma (HCC), especially in those individuals chronically infected with the hepatitis C virus (HCV) or the hepatitis B virus (HBV). However, these findings have not been consistently replicated in the literature due to limited sample sizes or different etiologies of HCC. Thus, the present systematic review and meta-analysis were performed to resolve this inconsistency. Methods. The databases PubMed, Embase, Web of Science, the China National Knowledge Infrastructure, and Scopus were searched up to December 12, 2022. Data from relevant studies were pooled, and odds ratios and 95% confidence intervals were calculated. Results. A total of 11 case-control studies encompassing 2,609 cases and 8,171 controls on rs1012068 and three encompassing 411 cases and 1,448 controls on rs5998152 were included. Results indicated that the DEPDC5 rs1012068 polymorphism did not significantly increase HCC risk in the total population (allelic model (OR = 1.32, 95% CI = 1.04–1.67, P  = 0.02); the recessive model (OR = 1.42, 95% CI = 0.96–2.10, P  = 0.08); the dominant model (OR = 1.43, 95% CI = 1.09–1.87, P  = 0.01); the homozygous model (OR = 1.61, 95% CI = 1.01–2.57, P  = 0.05); the heterozygous model (OR = 1.39, 95% CI = 1.09–1.79, P  = 0.009)). Subgroup analyses based on ethnicity and etiology revealed that the rs1012068 polymorphism, under all five genetic models, was associated with increased HCC risk in Asians or in individuals with chronic HBV infection but not in individuals with chronic HCV infection. A significant association was also observed between rs5998152 and HCV-related HCC risk in Asians chronically infected with HCV under allelic, dominant, and heterozygous models. Conclusion. Our study suggests that the DEPDC5 rs1012068 polymorphism increases HCC risk, especially in Asians with chronic HBV infection, while the rs5998152 polymorphism increases HCC risk in Asians with chronic HCV infection.

Plant communities show some kind of interspecific relationship and different niche characteristics through the sharing and competition of resources in the living environment, which is of great significance for interpreting the response mechanism of vegetation to the environment. This study analyzes the niche breadth, niche overlap, and interspecific relationships of plant species in the study area by using ecological statistics. Although there are certain correlations among the species in the Hunshandake Sandy Land, the relationship is relatively loose and the whole is in an unstable stage; the plants with relatively wide niche under three types of site types in the eastern margin of the Hunshandake Sandy Land The species are Quercus mongolica (Betula platyphylla), Malus baccata + Spiraea pubescens, Ribes diacanthum (Ostryopsis davidiana) of the leeward slope; Ulmus pumila+ Ribes diacanthum and Siberian apricot (Ribes pulchellum ) on the windward slope; Ulmus pumila and Malus baccata + Spiraea trilobata, Rosa davurica (Kochia prostrata) on the hilly land. The combination of the leeward slope niche overlap is Betula platyphylla and Malus baccata + Spiraea pubescens, Ostryopsis davidiana; Ulmus pumila + Ribes pulchellum, Kochia prostrata on the windward slope; the hilly land for Malus baccata, Ulmus pumila + Spiraea trilobata.

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